In order to evaluate the effect of drought stress on cultivars and advanced lines of autumn wheat that were in the final stages of release as bread wheat varieties in the Research Center of West Azerbaijan Province and to determine their relative tolerance using the selection efficiency of drought resistance indices (SSI, STI, TOl, MP, GMP, HARM,). Two separate experiments in a randomized complete block design with three replications under two conditions of stress and no drought stress in the research farm of Islamic Azad University, Tabriz Branch during the 2016-2017. The results of combined analysis of variance showed that drought stress significantly reduces grain yield. In the absence of drought stress, genotypes 4, 12 and 13 had the highest grain yield, but in drought stress conditions, no significant difference was observed between the studied genotypes in terms of grain yield. The results of correlation analysis between stress tolerance indices and grain yield showed that grain yield under stress (Y s) with STI, HARM and GMP indices have a positive and very significant correlation and these indices can be a good criterion for the drought tolerant lines. Also, the results of principal component analysis showed that these four indicators were the best indicators for identifying stress tolerant cultivars. In fact, these indices distinguished Fernandez Group A genotypes better than other indices. In cluster analysis, the studied genotypes were divided into 3 groups based on all indices of drought tolerance in both non-stress and stress conditions. Genotypes 4, 11 and 12, which were introduced as the most tolerant genotypes in this experiment, along with several other genotypes, were in the second group, and this group had a higher average than the total average in terms of most drought tolerance indices. The percentage of deviation was lower than the average of this group compared to the other two groups and confirmed the results of other methods used in this study. Considering the results of the numerical value of the indices and also their correlation with grain yield in the absence of stress and drought stress, STI, MP, GMP and HARM indices are the best stress tolerance indices and genotypes No. 4, 11 and 12 were identified as the most tolerant genotypes under study.